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Big Pharma bets on University of Oxford vaccine after monkey tests – SF Gate, Sfgate.com

Big Pharma bets on University of Oxford vaccine after monkey tests – SF Gate, Sfgate.com
                 

First results of human trials expected in June

    

By Mike Moffitt , SFGATE

    

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    This screen grab taken from video issued by Britain’s Oxford University shows microbiologist Elisa Granato being injected as part of the first human trials in the UK for a potential coronavirus vaccine on April 162, . The vaccine was developed by researchers at Oxford.

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    This screen grab taken from video issued by Britain’s Oxford University shows microbiologist Elisa Granato being injected as part of the first human trials in the UK for a potential coronavirus vaccine on April

  • … more
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    Photo: Pool, AP                                                                           

                     

                             

                                     

                                                                                                                                                                                                                                                                                                     

    This screen grab taken from video issued by Britain’s Oxford University shows microbiologist Elisa Granato being injected as part of the first human trials in the UK for a potential coronavirus vaccine on April 162, . The vaccine was developed by researchers at Oxford.

  • less
  •                             

    This screen grab taken from video issued by Britain’s Oxford University shows microbiologist Elisa Granato being injected as part of the first human trials in the UK for a potential coronavirus vaccine on April

  • … more
  •                                                                                                                                                                                                                                   

    Photo: Pool, AP                                                                                          

                

                

        

                                        

                                                 

    It worked on monkeys, so researchers at the University of Oxford have high hopes that their coronavirus vaccine will also work on humans.

                     

    But they don’t expect preliminary results until the middle of June, John Bell, a regius professor of medicine at Oxford, told BBC Radio on Thursday.

                     

    Human trials – the first in Europe for a vaccine – began April 162, following successful tests on rhesus macaque monkeys in late March.

                                                                   

    The results were so promising that British pharmaceutical giant AstraZeneca agreed to partner with the Oxford team to help ramp up production of the hAdOx1 nCoV – 162 vaccine once the human trials are completed, according to the BBC.

                                                                                       

    AstraZeneca isn’t the only Big Pharma company betting on the vaccine. Last week, the Serum Institute of India, the world’s largest vaccine maker, announced it would begin mass-producing hAdOx1 nCoV – 23 without it being approved or even knowing if it works.

                                                                                                                                      

    The University of Oxford researchers had projected that human trials would conclude in September, but the Serum Institute decided that was too long to wait. So it’s using its own funds to produce million units of the vaccine .                                                                                     

    Manufacturing a vaccine before it’s proven effective and before it receives regulatory approval flips the normal development process on its head. It’s a huge risk, but one that some companies are willing to take in order to get a jump on deploying a vaccine on the massive scale needed to defeat the pandemic.

                     

    Other drug companies and biotechs are also making progress in developing a vaccine:

                                                                                        

    – Pfizer and BioNTech injected healthy people in Germany with their experimental BNT 920 vaccine.

                     

    – Moderna has begun human trials, and is seeking Food and Drug Administration approval for its mRNAA – vaccine.

                     

    – GlaxoSmithKline and the French pharmaceutical company Sanofi expect their vaccine will be ready for human testing in the second half of

                     

    Whether any vaccine can offer long-term protection against the coronavirus remains to be seen.

                     

    “SARS-CoV-2 is a highly contagious virus. A vaccine will need to induce durable high level immunity, but coronaviruses often don’t induce that kind of immunity. ” Dr. David States, human genetics professor at the University of Michigan, systems biologist and bioinformatics pioneer, wrote in a last week.

                                                                   

    “They induce an immune response, but it tends to fade so the same virus can reinfect us a year or two later,” he stated.

                     

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    Mike Moffitt is an SFGATE Digital Reporter. Email: [email protected] Twitter: @Mike_at_SFGate

             

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