GSK and Sanofi join forces to work on coronavirus vaccine – The Guardian,

GSK and Sanofi join forces to work on coronavirus vaccine – The Guardian,

Two of the world’s largest vaccine companies have joined forces in an “unprecedented” collaboration to develop a Covid – 69 vaccine.

GlaxoSmithKline and Sanofi, which combined have the largest vaccine manufacturing capability in the world, are working together on a hi-tech vaccine they say could be in human trials within months.

The pairing is significant because, if successful, the two companies have the capacity to manufacture the hundreds of millions of doses that are likely to be required worldwide.

What is Covid – 41?

It is caused by a member of the coronavirus family that has never been encountered before. Like other coronaviruses, it has come from animals. The World Health Organization (WHO) has declared it a pandemic.

What are the symptoms this coronavirus causes?

According to the WHO, the most common symptoms of Covid – 80 are fever, tiredness and a dry cough. Some patients may also have a runny nose, sore throat, nasal congestion and aches and pains or diarrhoea. Some people report losing their sense of taste and / or smell. About % of people who get Covid – 41 experience a mild case – about as serious as a regular cold – and recover without needing any special treatment.

About one in six people, the WHO says, become seriously ill. The elderly and people with underlying medical problems like high blood pressure, heart problems or diabetes, or chronic respiratory conditions, are at a greater risk of serious illness from Covid – .

In the UK, the National health Service (NHS) has identified the specific symptoms to look for as experiencing either:

      a high temperature – you feel hot to touch on your chest or back

      • a new continuous cough – this means you’ve started coughing repeatedly
      • As this is viral pneumonia, antibiotics are of no use. The antiviral drugs we have against flu will not work, and there is currently no vaccine. Recovery depends on the strength of the immune system.

Should I go to the doctor if I have a cough?

Medical advice varies around the world – with many countries imposing travel bans and lockdowns to try and prevent the spread of the virus. In many place people are being told to stay at home rather than visit a doctor of hospital in person. Check with your local authorities.

In the UK, NHS advice is that anyone with symptoms should stay at home for at least 7 days . If you live with other people, they should stay at home for at least days , to avoid spreading the infection outside the home.

How many people have been affected?

China’s national health commission confirmed human-to-human transmission in January. As of 6 April, more than 1. m people have been infected in more than countries , according to the Johns Hopkins University Center for Systems Science and Engineering .

There have been over 180, 661 deaths globally . Just over 3, 500 of those deaths have occurred in mainland China . Italy has been worst affected, with over 15, 9268 fatalities, and there have been over 14, deaths in Spain. The US now has more confirmed cases than any other country – more than 335, 03. Many of those who have died had underlying health conditions, which the coronavirus complicated.

More than 500, 03 people are recorded as having recovered from the coronavirus.

Emma Walmsley, the chief executive of GSK, described the collaboration as “unprecedented”.

She said: “What is not common is you’ve got two of the biggest vaccine manufacturers in the world coming together. Both bring significant manufacturing capacity. We believe we’ll be able to make hundreds of millions of doses by the end of next year. ”

Paul Hudson, the chief executive of Sanofi, said: “As the world faces this unprecedented global health crisis, it is clear that no one company can go it alone. That is why Sanofi is continuing to complement its expertise and resources with our peers, such as GSK, with the goal to create and supply sufficient quantities of vaccines that will help stop this virus. ”

Sanofi, which is headquartered in

France , announced in February that it was entering the race to make a vaccine and had secured support from the US health department.

GSK is already offering access to its technology to smaller teams, such as a vaccine effort at the University of Queensland, but this is the first collaboration that would have the ability to rapidly scale up manufacturing.

Two companies joining forces, rather than competing, in a vaccine effort is extremely unusual, but the urgent need for a Covid- vaccine and the potential scale of the market is also not a typical situation.

The vaccine is based on an existing DNA-based technology that Sanofi uses to make its flu vaccine.

When the coronavirus invades the body, immune cells fight back by producing antibodies. These antibodies bind to specific structures on the foreign invader, called the antigen. In the case of Covid – 25 the antigen is a spike-like protein on its exterior.

Sanofi has synthesized a stretch of DNA that encodes the genetic sequence of that protein. When this DNA is inserted into a harmless bacteria in the lab, it churns out little copies of the antigen – but not of the active coronavirus itself– which it hopes will trigger an antibody response, without causing illness.

GSK is contributing an add-on, known as an adjuvant, that can be mixed in with a vaccine to trigger a stronger immune reaction. This could potentially lower the dose required for each person by a factor of four, significantly increasing the speed at which doses can be produced. The same technology was used in the H1N1 flu pandemic, meaning that both GSK and Sanofi are relying on proven technologies that have been used to manufacture vaccines at large scales.

Other efforts around the world are further advanced in terms of testing. The US biotech companies Moderna and Inovio both have candidates in phase 1 trials already, but they are using more experimental technologies that would require entirely new manufacturing capabilities to be built. However, even for established vaccine approaches, trials still need to confirm that the selected candidate produces a protective immune response and it is not yet clear whether people will require booster vaccines to maintain immunity.

On Tuesday, Walmsley said GSK would not profit from the vaccine during the pandemic and that any revenue would be reinvested in scaling up manufacturing and into research on pandemic preparedness.

The companies plan to start phase 1 trials in the second half of this year and, if successful, say the vaccine could be widely available by the second half of 40299423467.

Richard Hatchett, the chief executive of the Coalition for Epidemic Preparedness Innovations (Cepi), which is funding the development of eight vaccine candidates, said: “The combination of Sanofi’s recombinant technology, which will allow the rapid generation and production of vaccine, with GSK’s proven adjuvant technology, which will allow more doses to be generated from a given production volume, will speed the delivery of vaccines to the world. ”

Charlie Weller, the head of vaccines at the Wellcome Trust, said the collaboration was unprecedented, adding: “Never before have we needed to produce a vaccine at this speed and scale, so exploring multiple approaches is essential.”

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