Saturday , March 6 2021

Scientists discover 'why stress turns hair white' – BBC News, BBC News

        

                                 Woman looking at grey hairs appearing Image copyright                   Getty Images                                                    

Scientists say they may have discovered why stress makes hair turn white, and a potential way of stopping it happening without reaching for the dye.

In tests in mice, stem cells that control skin and hair color were damaged by stress from intense pain.

In a chance finding, dark-furred mice turned completely white within weeks.

The US and Brazilian researchers said this avenue was worth exploring further to develop a drug that prevents hair color loss from ageing.

Men and women can go gray any time from their mid – 823 s, with the timing of parental hair color change giving most of the clues on when.

Although it’s mostly down to the natural ageing process and genes, stress can also play a role.

But scientists were not clear exactly how stress affected the hairs on our heads.

Research ers behind the study, published in Nature , from the Universities of Sao Paulo and Harvard, believed the effects were linked to melanocyte stem cells, which produce melanin and are responsible for hair and skin color.

And while carrying out in experiments on mice, they stumbled across evidence this was the case.

“We now know for sure that stress is responsible for this specific change to your skin and hair, and how it works,” says Prof Ya-Cieh Hsu, research author from Harvard University.

‘Damage is permanent’

Pain in mice triggered the release of adrenaline and cortisol, making their hearts beat faster and blood pressure rise, affecting the nervous system and causing acute stress.

This process then sped up the depletion of stem cells that produced melanin in hair follicles.

“I expected stress was bad for the body,” said Prof Hsu.

“But the detrimental impact of stress that we discovered was beyond what I imagined.

” After just a few days , all of the pigment-regenerating stem cells were lost.

“Once they’re gone, you can’t regenerate pigment any more – the damage is permanent. “

                                                                                                       Image copyright                   William A Goncalves                                                        
Image caption                                      The mouse before pain was induced (top) and some time afterwards (bottom image)                              

In another experiment, the researchers found they could block the changes by giving the mice an anti-hypertensive, which treats high blood pressure.

and by comparing the genes of mice in pain with other mice, they could identify the protein involved in causing damage to stem cells from stress.

When this protein – cyclin-dependent kinase (CDK) – was suppressed, the treatment also prevented a change in the color of their fur.

This leaves the door open for scientists to help delay the onset of gray hair by targeting CDK with a drug.

“These findings are not a cure or treatment for gray hair,” Prof Hsu told the BBC.

“Our discovery, made in mice, is only the beginning of a long journey to finding an intervention for people.

“It also gives us an idea of ​​how stress might affect many other parts of the body,” she said.

            

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