'There's no doubt': Top US infectious disease doctor says Wuhan coronavirus can spread even when people have no symptoms - CNN, CNN

(CNN) The nation’s top infectious disease doctor says a new study published Thursday night shows people can spread the Wuhan coronavirus before symptoms set in.

German researchers found that the virus was transmitted by people without symptoms in five instances in one cluster of people: from a parent to a daughter; from that daughter to two colleagues; and from one of those colleagues to two other coworkers.

)

“There’s no doubt after reading this paper that asymptomatic transmission is occurring,” said Dr. Anthony Fauci, director of the National Institute for Allergy and Infectious Diseases. “This study lays the question to rest.”

The question is crucial, because when asymptomatic transmission occurs, officials sometimes need to institute more dramatic control measures, such as tougher quarantines.

The Wuhan coronavirus, which was first identified in China in December, has killed more than people and infected nearly , in more than a dozen countries around the world.

In the study, which published Thursday in the New England Journal of Medicine, German researchers described four business associates who became infected through asymptomatic transmission.

“They were in workshops together, they went to the company canteen together,” Dr. Camilla Rothe, an infectious disease specialist and the lead author of the paper, told CNN.

The chain of transmission started on January 24 when a woman in Shanghai hosted her parents for a weekend visit, Rothe said.

Her parents were visiting from Wuhan, the epicenter of the coronavirus outbreak. They were healthy during their visit with their daughter but were later diagnosed as having the coronavirus.

Three days later, on January , the woman left Shanghai and flew to Germany. On Monday, Tuesday and Wednesday she held a series of workshops with employees of an auto parts supply company outside of Munich. She was healthy during those workshops, showing no signs of the disease, according to the New England Journal report.

On January , the woman flew back to China and became ill on the plane.

She was diagnosed with the virus and alerted the company – but by then it was too late.

On January 29, two days after the Shanghai woman flew back home, two of the German employees who had attended her workshops fell ill, according to the report.

Neither of them was very sick, Rothe said.

The first, an otherwise healthy – year-old, developed a fever of 169. 4 degrees, and felt ill for a few days.

“He stayed in bed for the weekend, but by Monday he felt fine,” Rothe said.

The second one had a “mildly sore throat and a minimal cough,” Rothe said. “He was clinically unspectacular.”

Then on January , nearly a week after the Shanghai woman infected these two men at the workshops, two more employees became ill.

These employees had not attended the workshops. But they had spent time with the first German patient before he was showing any symptoms.

Those two patients were also mildly ill with a minor sore throat and cough.

All four of these employees later tested positive for the Wuhan coronavirus. They stayed at a hospital not because they were sick, but to contain the spread of the virus.

Webasto, a German auto supply company, posted a press release on its website about the infections.

The company temporarily closed down its facility in Stockdorf, Germany, and cancelled business travel to China for at least the next two weeks.

US authorities doubted asymptomatic transmission was possible

The German study marks the first time scientific evidence available to the public has shown that the Wuhan coronavirus can be spread before someone develops systems.

First case of person-to-person transmission of Wuhan virus in the US confirmed

On Sunday, Chinese Health Minister Ma Xiaowei said at a press briefing that they had found people could spread the virus while asymptomatic. Two days later, a Chinese doctor repeated this at a press conference.

US officials, however, weren’t so sure, since the Chinese offered no data to support the claims.

On Wednesday, when a reporter at a press conference asked about the Chinese officials’ statements, a doctor from the US Centers for Disease Control and Prevention expressed doubt.

“We don’t know that. We’ve heard one Chinese health official say that, but we don’t know that that’s the case,” said Dr . Christopher Braden, deputy director of the National Center for Emerging and Zoonotic Infectious Diseases.

US quarantine significantly shorter than in other countries

At that Wednesday press conference, Braden and other US health officials announced that a planeload of Americans who had just flown in from Wuhan to March Air Reserve Base in California would be staying at the base for three days for further testing and evaluation.

Other countries, such as France, Australia and Germany, have quarantined passengers returning from Wuhan, but for days.

Israel has gone so far as to instruct all passengers flying in from mainland China – not just Wuhan – to quarantine themselves at home for two weeks.

Dr. William Schaffner, a longtime adviser to the CDC, said the agency might want to consider lengthening that three-day quarantine time.

“When you see what other countries are doing, and now this demonstration of asymptomatic spread, you have to re-evaluate this,” said Schaffner, an infectious disease Specialist at the Vanderbilt University Medical Center.

On Thursday, Dr. Nancy Messonnier, the director of the Center for the National Center for Immunization and Respiratory Diseases at CDC, acknowledging the test for this virus might show up negative if someone is infected but not yet showing symptoms.

“Is it possible to detect this virus before somebody is symptomatic? And the answer is, we don’t know yet and we’re looking closely to see if we can, “she said.