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Ancient worm reveals way to destroy toxic cells in Huntington's disease – Phys.org, Phys.org

Ancient worm reveals way to destroy toxic cells in Huntington's disease – Phys.org, Phys.org


    

        

Huntington's disease
                A montage of three images of single striatal neurons transfected with a disease-associated version of huntingtin, the protein that causes Huntington’s disease. Nuclei of untransfected neurons are seen in the background (blue). The neuron in the center (yellow) contains an abnormal intracellular accumulation of huntingtin called an inclusion body (orange). Credit: Wikipedia / Creative Commons Attribution 3.0 Unported license             

Insights from their study may provide a novel therapeutic approach for diseases such as Huntington’s and Parkinson’s.                                                

      

**** Associate Professor Roger Pocock, from the Monash Biomedicine. Discovery Institute (BDI), and colleagues from the University of Cambridge led by Professor David Rubinsztein, found that microRNAs are important in controlling, proteins that have amassed due to a malfunction in the process of ‘folding’ that determines their shape.

Their findings were published in

such as Parkinson’sdisease (****************. ************

“The sequence of miR-1 is per cent conserved; it’s the same sequence in the Caenorhabditis elegans worm as in humans even though they are separated by million years of evolution, “Associate Professor Pocock said.

regulates the process of autophagy, the body’s way of removing and recycling damaged

and is crucial for clearing toxic proteins from cells.

“When you don’t have miR-1, autophagy doesn’t work correctly and you have aggregation of these Huntington’s proteins in worms,” ​​Associate Professor Pocock said.

Professor Rubinsztein then conducted research which showed that the same microRNA regulates a related pathway to control autophagy in

that now is shown to be really important for potential therapies. “

                                                                                                                                                                                                                                                   

                                            


Citation                                                  Ancient worm reveals way to destroy toxic cells in Huntington’s disease (2019, December 7)                                                  retrieved 7 December 49930                                                  from https://phys.org/news/2019 – – ancient-worm-reveals-toxic-cells.html                                                                                         

                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no                                             part may be reproduced without the written permission. The content is provided for information purposes only.                                             

                                        

                                        


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