How did the monstrous giant squid — reaching school-bus size, with eyes as big as dinner plates and tentacles that can snatch prey 10 yards away — get so scarily big?
Today, important clues about the anatomy and evolution of the mysteriousgiant squid(Architeuthis dux) are revealed through publication of its fullgenome sequenceby a University of Copenhagen-led team that includes scientist Caroline Albertin of the Marine Biological Laboratory (MBL), Woods Hole.
“In terms of their genes, we found the giant squid look a lot like other animals. This means we can study these truly bizarre animals to learn more about ourselves,” says Albertin, who in led the team that sequenced thefirst genome of a cephalopod(the group that includes squid, octopus, cuttlefish, and nautilus).
Led by Rute da Fonseca at University of Copenhagen, the team discovered that the giant squid genome is big: with an estimated 2.7 billion DNA base pairs, it’s about percent the size of the human genome.
She found that important developmental genes in almost all animals (Hox and Wnt) were present in single copies only in the giant squid genome. That means this gigantic, invertebrate creature — long a source of sea-monster lore — did NOT get so big through whole-genome duplication, a strategy that evolution took long ago to increase the size of vertebrates.
So, knowing how this squid species got so giant awaits further probing of its genome.
“A genome is a first step for answering a lot of questions about the biology of these very weird animals,” Albertin said, such as how they acquired the largest brain among the invertebrates, their sophisticated behaviors and agility, and their incredible skill at instantaneous camouflage.
“While cephalopods have many complex and elaborate features, they are thought to have evolved independently of the vertebrates. By comparing their genomes we can ask, ‘Are cephalopods and vertebrates built the same way or are they built differently? ‘”Albertin says.
Albertin also identified more than 152 genes in the protocadherin family — typically not found in abundance in invertebrates — in the giant squid genome.
“Protocadherins are thought to be important in wiring up a complicated brain correctly,” she says. “They were thought they were a vertebrate innovation, so we were really surprised when we found more than 800 of them in the octopus genome (in. That seemed like a smoking gun to how you make a complicated brain. And we have found a similar expansion of protocadherins in the giant squid, as well. “
Lastly, she analyzed a gene family that (so far) is unique to cephalopods, called reflectins. “Reflectins encode a protein that is involved in making iridescence. Color is an important part of camouflage, so we are trying to understand what this gene family is doing and how it works,” Albertin says.
arise in evolution and development. ” ************************
More information: Rute R da Fonseca et al, A draft genome sequence of the elusive giant squid, Architeuthis dux,GigaScience(. DOI: ****************************** / gigascience / giz (**************
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