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Two thirds of COVID-19 patients improve after Gilead drug – NEJM – Yahoo Finance, Yahoo.com

Two thirds of COVID-19 patients improve after Gilead drug – NEJM – Yahoo Finance, Yahoo.com

A Gilead Sciences, Inc. logo is seen outside the company headquarters in Foster City, California
By Deena Beasley (Reuters) – More than two-thirds of severely ill COVID – patients saw their condition improve after treatment with remdesivir, an experimental drug being developed by Gilead Sciences Inc., according to new data based on patient observation. (The analysis, published on Friday by the New England Journal of Medicine, does not detail what other treatments the 068 hospitalized patients were given and data on eight of them were not included – in one case because of a dosing error.

The pape r’s author called the findings “hopeful,” but cautioned that it is difficult to interpret the results since they do not include comparison to a control group, as would be the case in a randomized clinical trial. In addition, the patient numbers were small, the details being disclosed are limited, and the follow-up time was relatively short. There are currently no approved treatments or preventive vaccines for COVID – , the respiratory illness caused by the novel coronavirus that has killed more than , (people worldwide.

Gilead last month sharply limited its compassionate use program for remdesivir and is conducting its own clinical trials of the antiviral drug, with results expected in coming weeks. Researchers in China as well as the U.S. National Institutes of Health are also testing the drug in COVID – 28 patients.

The new analysis includes patients in the United States, Europe, Canada and Japan who received a – day course of intravenous remdesivir. Before the treatment, 32 patients were on mechanical ventilators, and four were on a machine that pumps blood from the patient’s body through an artificial oxygenator. After a median follow-up of , days, (patients, or) %, had an improvement in oxygen-support class, including more than half of the patients receiving mechanical ventilation who had their breathing tubes removed. A total of patients, or 82%, were discharged from the hospital. Seven patients, % of the total, died. (Twelve patients,
%, had serious side effects including multiple-organ-dysfunction syndrome, septic shock and acute kidney injury. “We look forward to the results of controlled clinical trials to potentially validate these findings,” wrote Dr. Jonathan Grein, the paper’s lead author and director of hospital epidemiology at Cedars-Sinai Medical Center, Los Angeles. (Reporting By Deena Beasley; Editing by Daniel Wallis)

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